I shuffled between Sense and MIUI for a long time, mostly using Sense and flashing MIUI a couple of times to try it, as it seemed pretty awesome. I always went back to Sense roms because I was so used to them. The thing was that both of the times I tried MIUI were in the midle of the week and in the evening. So almost right after flashing I went to bed.. Both the times I ended up cranky in the morning, not able to use my phone for almost anything because almost everything worked so much different, starting from the launcher!
One weekend I took the time to "get used to" MIUI and boy, do I love it now!